Selected genetic factors associated with male infertility

Pnm-4: Risk Factors Associated with Infertility

Background Infertility is the inability to conceive children after one year of unprotected intercourse. The estimated prevalence of infertility in Canada is 11.5-15.7%. Fertility problems affect approximately one in seven couples in the United Kingdom (UK). Infertility occurs in conditions in which the pregnancies end with recurrent miscarriages (ASR) or birth of a child with multiple congenita...

Gene Mutations Associated with Male Infertility

Genetic Testing in Male Infertility

Infertility is a major health problem which affects approximately 22% of married couples in reproductive age. The apparent increased incidence of male infertility, in parallel with the widespread use of in vitro fertilization (IVF), raises concern as to the impact of advanced assisted conception techniques in transmitting genetic anomalies to the offspring. Recent research has widely focused on...

Genetic Causes of Male Infertility

Infertility is a major health problem today, affecting about 15.0% of couples trying to have a child. Impaired fertility of the male is causative in 20.0% of infertile couples and contributory in up to another 30.0-40.0%. Infertility already affects about 5.0-7.0% of the general male population and may further increase in the future, considering the apparent trend of declining sperm count in in...

Genetic evaluation of male infertility

Men with severe oligospermia (<5 million sperm/mL ejaculate fluid) or azoospermia should receive genetic testing to clarify etiology of male infertility prior to treatment. Categorization by obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is critical since genetic testing differs for the former with normal testicular function, testicular volume (~20 mL), and follicle-stimulati...